hTERT Promoter

Telomerase reverse transcriptase (hTERT in humans) is a catalytic subunit of the enzyme telomerase, which, together with the telomerase RNA component (TERC), comprises the most important unit of the telomerase complex. Mutations occur at four specific sites in the hTERT promoter in 75% of glioblastomas and melanomas, but the mechanism by which the mutations affect […]